How long does IV nicardipine last?

Following infusion, nicardipine plasma concentrations decline tri-exponentially, with a rapid early distribution phase (α-half-life of 2.7 minutes), an intermediate phase (β-half-life of 44.8 minutes), and a slow terminal phase (γ-half-life of 14.4 hours) that can only be detected after long-term infusions.

Does nicardipine need to be refrigerated?

Cardene® I.V. (nicardipine hydrochloride) is available in packages of 10 ampuls of 10 mL as follows: 25 mg (2.5 mg/mL), NDC 67286-0812-3. Store at controlled room temperature 20º to 25ºC (68º to 77ºF).

How do you administer nicardipine IV?

Nicardipine hydrochloride injection is administered by slow continuous infusion at a CONCENTRATION OF 0.1 MG/ML. Each vial (25 mg) should be diluted with 240 mL of compatible intravenous fluid (see below), resulting in 250 mL of solution at a concentration of 0.1 mg/mL.

Can nicardipine be given IV?

Intravenous (IV) nicardipine (Cardene IV), which demonstrates a relatively rapid onset/offset of action, is used in situations requiring the rapid control of blood pressure (BP). IV nicardipine was as effective as IV nitroprusside in the short-term reduction of BP in patients with severe or postoperative hypertension.

Can nifedipine be given IV?

In conclusion, the intravenous infusion of nifedipine in a dose 1.25 mg/h, seems to control the hypertensive phases of blood pressure, without dropping to any unduly low level, risking undesirable side effects in elderly hypertensive patients during perioperative period.

Why do you titrate nicardipine drip?

Titrate dose to achieve the desired blood pressure reduction. Individualize dosage depending on the blood pressure to be obtained and the response of the patient.

What do you mix nicardipine with?

Dilute each ampul (25 mg/10 ml) with 240 ml normal saline to make 250 ml of IV solution. The final concentration should be 0.1 mg/ml. If a peripheral vein is used, the infusion site should be changed every 12 hours. Initiate therapy at 5 mg/hour as a continuous IV infusion.

How do you titrate down nicardipine drip?

[ ] NiCARdipine drip: 40mg/200ml, IV, Routine, T;N, Titrate, Comment: Start at 5 mg/hr and increase by 2.5 mg/hr as often as every 15 minutes to achieve MAP goal. Maximum dose is 15 mg/hr. Begin to wean continuous infusion 6-12 hours after beginning oral medications.

How do you dilute nicardipine infusion?

Is nifedipine an IV?

Which calcium channel blocker can be given IV?

Clevidipine is an intravenous (IV) dihydropyridine calcium-channel blocker (CCB) that is approved for the reduction of blood pressure (BP) when oral therapy is not feasible or not desirable.

How do you administer nifedipine?

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach. If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine.