Can you take fluoxetine with tamoxifen?
Tamoxifen and fluoxetine are two of the most commonly prescribed medicines in the UK and as such there is likely to be some overlap of the two drugs in individual patients. A recent study has shown that fluoxetine could actually reduce the action and effectiveness of tamoxifen in preventing the growth of breast cancer.
What antidepressant works well with tamoxifen?
Venlafaxine has little or no effect on the metabolism of tamoxifen and may be considered the safest choice of antidepressants. Desvenlafaxine is not metabolized by the P450 system and may consequently be another option.
Do antidepressants reduce the effectiveness of tamoxifen?
A recent study published in the British Medical Journal provides evidence that antidepressants which are potent inhibitors of CYP2D6 enzymes may decrease the effectiveness of tamoxifen and may result in worse outcomes.
What antidepressant should be avoided with tamoxifen?
Caution should be used when it is taken along with antidepressant medications, as some of them interfere with the way tamoxifen works at decreasing the risk of breast cancer recurrence. Antidepressants such as Paxil or Prozac should be avoided, while others, such as Celexa or Lexapro, may be a safer option.
Do SSRIs interact with tamoxifen?
Some SSRIs but not others inhibit CYP2D6, conceivably attenuating or even abolishing the benefits of tamoxifen. The importance of this potential interaction is amplified by three factors. First, tamoxifen is a monumental treatment, conferring dramatic reductions in breast cancer recurrence and associated mortality.
Does taking tamoxifen cause anxiety?
While studies have shown tamoxifen significantly improves survival rates for women with breast cancer by blocking the effects of estrogen, clinical evidence suggests the drug increases rates of anxiety and the incidence of hot flashes, both of which may result from reduced action of estrogen.
Why does tamoxifen cause depression?
Tamoxifen is known to trigger depressive symptoms as a result of its anti-estrogenic activity.
What drugs should not be taken with tamoxifen?
Is there anything that I should avoid eating or drinking while on Tamoxifen?
- Grapefruit. Grapefruit and grapefruit juice are well-known disruptors of numerous medications 2.
- Turmeric/ Curcumin.
- Black cohosh.
Does tamoxifen cause anxiety and depression?
Can you take fluoxetine with HRT?
Conclusions: The effect of fluoxetine plus HRT on menopausal depression is significantly superior than that of HRT only and the difference becomes more obvious with treatment time. Both groups could ameliorate the climacteric symptoms with the effect of fluoxetine plus HRT more obvious.
How common is depression with tamoxifen?
Reported rates of tamoxifen-induced depression vary from 1% to 17%. As noted, we have found no reported case of suicide linked to tamoxifen. The relationship between estrogen and mood is well known.