What is FTD and PSP?

Frontotemporal dementia or FTD is a progressive disorder of the brain. It can can affect behaviour, language skills and movement. FTD commonly overlaps with parkinsonian disorders causing problems with movement. One of these is called progressive supranuclear palsy or PSP.

What is 18F FP CIT?

18F-FP-CIT Positron Emission Tomography for Correlating Motor and Cognitive Symptoms of Parkinson’s Disease – PMC.

What is FP CIT spect?

(123I)FP-CIT SPECT is an established biomarker for dementia with Lewy bodies (DLB) versus Alzheimer’s disease. Little is known about the clinical course of patients with symptoms of DLB and a normal (123I)FP-CIT SPECT and patients not fulfilling the DLB criteria with an abnormal scan.

Is PSP a dementia?

Progressive supranuclear palsy (PSP) is a condition that causes both dementia and problems with movement. It is a progressive condition that mainly affects people aged over 60. The word ‘supranuclear’ refers to the parts of the brain just above the nerve cells that control eye movement.

What does a Spect scan do?

A single-photon emission computerized tomography (SPECT) scan lets your doctor analyze the function of some of your internal organs. A SPECT scan is a type of nuclear imaging test, which means it uses a radioactive substance and a special camera to create 3-D pictures.

Is PSP worse than Parkinsons?

On average, PSP gets worse quicker than Parkinson’s and doesn’t respond as well to medications. People with Parkinson’s usually bend forward, while people with PSP stand very straight, or even slightly backwards. Problems with swallowing and with speaking appear early with PSP and they are far more severe.

Does 18f-fp-CIT pet differentiate progressive supranuclear palsy and frontotemporal dementia?

The role of 18F-FP-CIT PET in differentiation of progressive supranuclear palsy and frontotemporal dementia in the early stage Eur J Nucl Med Mol Imaging.

What is the concordance of 18f-fp-CIT PET images?

Dual phase 18F-FP-CIT PET images showed similar or higher than 90% concordance in all groups. 18F-FDG PET images showed equal or greater than 90% concordance in subjects with non-DP, MSA, and PSP, but only 33.3% concordance in subjects with IPD.

Is dual phase 18f-fp-CIT pet an alternative to the combination of 18F-FDG PET?

In summary, dual phase 18F-FP-CIT PET may represent a powerful alternative to the combination of 18F-FDG PET and delayed 18F-FP-CIT PET for the detection and differential diagnosis of parkinsonian disorders. Acknowledgements

What is the resolution of 18f-fp-CIT pet?

18F-FP-CIT PET was performed using a Biograph 40 TruePoint PET/CT camera (Siemens Medical Systems, USA), which provides an in-plane spatial resolution of 2.0 mm full width at half maximum at the center of the field of view.