What is the concentration of propofol?

Propofol 10 mg/ml Emulsion for injection/infusion. Each ml of emulsion for injection/ infusion contains 10 mg of propofol. Sodium 0.035 mg. Emulsion for injection/infusion.

What is the bioavailability of propofol?

The bioavailability (F), based on AUC(0−∞), of propofol was 30% for oral administration and 37% for ID administration.

What is propofol volume of distribution?

A glucuronide conjugate accounts for about 50% of the administered dose. Propofol has a steady-state volume of distribution (10-day infusion) approaching 60 L/kg in healthy adults.

Does propofol have high volume of distribution?

Propofol is 98% protein bound, and it has the highest volume of distribution of any induction agent.

How many grams of fat are in propofol?

Propofol is a lipid-soluble, short-acting IV hypnotic/sedative administered continuously to provide sedation in mechanically ventilated ICU patients. Propofol is available in an emulsion similar in composition to a 10% parenteral lipid emulsion which provides 1.1kcals/mL as fat.

How much propofol is lethal?

Of interest, blood levels of propofol in the majority of propofol related deaths were within or below the therapeutic range (1.3 – 6.8 µg/mL), indicating that the mechanism of death was likely due to respiratory depression with subsequent hypoxia (3, 34).

What is half-life of propofol?

Half-life: Propofol is bi-phasic, with its initial half-life being relatively quick, around 40 minutes, and its terminal half-life usually being 4 to 7 hours. Context-sensitive half-time may be up to 1 to 3 days after a 10-day infusion. The clinical effect of propofol is much shorter in duration.

Is propofol water soluble?

Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility.

How is propofol distributed?

Distribution. After intravenous administration, propofol is extensively bound to the plasma proteins (predominantly albumin) and erythrocytes. The free fraction is only 1.2–1.7%.

What is effect site concentration?

Effect site concentration is the concentration of drug at the site of its biological activity, eg. bound to the receptors. Effect site concentration is proportional to pharmacological effect, whereas plasma concentration may not be.

Are propofol metabolites active?

In humans, propofol produces inactive metabolites. It undergoes direct polymorphic O-glucuronidation in humans to propofol-glucuronide and hydroxylation to 2,6-diisopropyl-1,4-quinol.

Is propofol lipophilic?

Propofol (Diprivan) is a phenolic derivative with sedative and hypnotic properties but is unrelated to other sedative/hypnotic agents. Formulated as an oil-in-water emulsion for intravenous use, it is highly lipophilic and rapidly crosses the blood-brain barrier resulting in a rapid onset of action.