Is histiocytosis X cancerous?

Is histiocytosis X cancerous?

Key Points. Langerhans cell histiocytosis is a rare disorder that can damage tissue or cause lesions to form in one or more places in the body. It is not known whether LCH is a form of cancer or a cancer-like disease.

Is histiocytosis a leukemia?

Acute lymphoblastic leukemia is more often associated with LC histiocytosis in children, whereas lymphoma and acute myeloid leukemia are more common in adults, which may reflect the frequency of these diseases in the respective populations.

What is histiocytosis X in adults?

Langerhans cell histiocytosis (LCH) in adults is a rare disorder that occurs when the body produces too many Langerhans cells (histiocytes), which are a type of white blood cell that helps fight infection.

Is histiocytosis X an autoimmune disease?

Langerhans cell histiocytosis historically was thought of as a cancer-like condition, but more recently researchers have begun to consider it an autoimmune phenomenon in which immune cells begin to overproduce and attack the body instead of fighting infection.

Is histiocytosis curable?

Usually a cure is linked to being in remission for a certain period of time. There is no established period of “non-active” disease before LCH is considered cured, but the chance for recurrence is low after five years from end of treatment.

Is LCH a leukemia?

Langerhans cell histiocytosis (LCH) is a non-malignant disorder, whether localized or disseminated, and usually has a favourable prognosis. A possible relationship between LCH and neoplastic diseases has not been assessed up to now even if a few cases have been recorded.

What are the symptoms of histiocytosis?


  • Abdominal pain.
  • Bone pain.
  • Delayed puberty.
  • Dizziness.
  • Ear drainage that continues long-term.
  • Eyes that appear to stick out more and more.
  • Irritability.
  • Failure to thrive.

How do you treat histiocytosis?

Histiocytosis Treatment

  1. Surgery. Sometimes histiocytosis involves only one area of the body.
  2. Radiation Therapy. Radiation therapy can be extremely effective for certain types of histiocytosis, especially Langerhans cell histiocytosis.
  3. Immunosuppressants and Chemotherapy.
  4. Targeted Medications for Histiocytosis.

Is there a cure for histiocytosis?

Surgery. Sometimes histiocytosis involves only one area of the body. This may be a particular bone, for example. In these cases, removing the tumor is the only treatment needed.

What causes histiocytosis?

The exact cause of histiocytosis is unknown. However, recent studies indicate that it is caused by the development and expansion of an abnormal Langerhans cell that subsequently leads to the accumulation of other cells of the immune system, resulting in collections or tumors in various areas of the body.

What is the survival rate of LCH?

Patients with low-risk LCH have an excellent prognosis and a long-term survival rate that may be as high as 99%; by contrast, patients with high-risk LCH have a survival rate close to 80%.

What is histiocytosis?

A histiocyte is a normal immune cell that is found in many parts of the body especially in the bone marrow, the blood stream, the skin, the liver, the lungs, the lymph glands and the spleen. In histiocytosis, the histiocytes move into tissues where they are not normally found and cause damage to those tissues.

What is crystal-storing histiocytosis in bone marrow?

Crystal-Storing Histiocytosis in Bone Marrow: A Clinicopathologic Study of Eight Cases and Review of the Literature BM-CSH is a rare phenomenon and exhibits a heterogeneous crystalline and histiocytic appearance warranting accurate recognition to avoid misinterpretation of a granulomatous condition or storage disorder.

What tests are used to diagnose histiocytosis?

Histiocytosis Diagnostic Tests Diagnostic tests include: a biopsy, in which a small sample of skin and/or bone is taken and examined under a microscope for abnormal cells; routine and sometimes specialized X-rays and scans of the bones, the skull, and the lungs; and blood tests.

What is Langerhans cell histiocytosis?

Histiocytosis, also referred to as Langerhans Cell Histiocytosis (LCH), and formally called Histiocytosis X, represents a group of rare disorders involving specific cells that normally have important roles as part of the immune system. While the cause of LCH is unknown, LCH can frequently behave like cancer and so is treated by cancer specialists.