What is a multinucleate cell?

A multinucleated cell is a unique form which is frequently observed in the normal tissue. Skeletal muscle is composed of bundles of multinucleate muscle fibers [1]. Osteoclasts induce multinucleation by the cell fusion of mononuclear cells to cover a large area for bone resorption [2].

How is a multinucleated cell formed?

The formation and growth of multinucleated myofibers or myotubes occur through a process known as myogenesis. During myogenesis, mononucleated myoblasts withdraw from the cell cycle, initiate muscle specific gene expression, and subsequently fuse with one another to form nascent, multinucleated myofibers.

Are mast cells multinucleated?

Bizarre multinucleate cells can be found in reactive, neoplastic and inflammatory lesions in many sites of the body, and mast cells can play a role in their morphogenesis.

Why are fibroblast cells multinucleated?

Primary-derived murine fibroblasts also form multinucleated cells, both in the presence or absence of co-cultured macrophages that increase during long-term culture (5–30 days). In contrast to 3T3 fusion, this primary cell phenomenon is not due to fibroblast fusion, but rather to nuclear division without cytokinesis.

Which muscle tissue is multinucleate?

Skeletal muscle fibers
Skeletal muscle fibers are cylindrical, multinucleated, striated, and under voluntary control.

What happens to multinucleated cells?

Mitosis in multinucleate cells can occur either in a coordinated, synchronous manner where all nuclei divide simultaneously or asynchronously where individual nuclei divide independently in time and space. Certain organisms may have a multinuclear stage of their life cycle.

Which type of muscle tissue is multinucleated?

Which cells in the body are multinucleated?

Some human cells have no nuclei at all, like red blood cells. Others, however, such as liver cells and some muscle cells, are multinucleated, meaning they have multiple nuclei.

How many nuclei does a fibroblast have?

Fibroblasts have a branched cytoplasm surrounding an elliptical, speckled nucleus having two or more nucleoli. Active fibroblasts can be recognized by their abundant rough endoplasmic reticulum.

What are multinucleated giant cells?

Multinucleated giant cells (MNGCs) are a special class of giant cell formed by the fusion of monocytes/macrophages abundantly found in human tissues.

Which of these cells are multinucleated?

Liver cells, muscle fibers, and osteoclasts are all normal cells that often have more than one nucleus. Cancerous cells and those infected with viruses can also have multiple nuclei at times. In addition to human cells, certain types of fungi have multinucleated cells. as well.

Why are muscle cells multinucleated?

Skeletal muscle cells are multinucleated because during prenatal development, several cells fuse together to create each developed muscle cell (hence the presence of several nuclei).